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KMID : 1144120200100010149
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Biomedical Engineering Letters
2020 Volume.10 No. 1 p.149 ~ p.161
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Porous electrospun poly(ε-caprolactone)/gelatin nanofibrous mat containing cinnamon for wound healing application: in vitro and in vivo study
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Salehi Majid
Niyakan Maryam
Ehterami Arian
Haghi-Daredeh Saeed
Nazarnezhad Simin
Abbaszadeh-Goudarzi Ghasem
Vaez Ahmad
Hashemi Seyedeh Fatemeh
Rezaei Nariman
Mousavi Seyed Reza
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Abstract
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In this study, cinnamon (cin) was loaded into poly(ε-caprolactone)/gelatin (PCL/Gel) nanofibrous matrices in order to fabricate an appropriate mat to improve wound healing. Mats were fabricated from PCL/COLL [1:1 (w/w)] solution with 1, 5 and 25% (w/v) of cinnamon. Prepared mats were characterized with regard to their microstructure, mechanical properties, porosity, surface wettability, water-uptake capacity, water vapor permeability, blood compatibility, microbial penetration and cellular response. The fabricated mats with and without cinnamon were used to treat the full-thickness excisional wounds in Wistar rats. The results indicated that the amount of cinnamon had a direct effect on porosity, mechanical properties, water uptake capacity, water contact angle, water vapor transmission rate and cell proliferation. In addition, the results of in vivo study indicated that after 14 days, the wounds which were treated with PCL/Gel 5%cin had better wound closure (98%) among other groups. Our results suggest that the cinnamon can be used as a suitable material for wound healing.
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KEYWORD
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Cinnamon, Electrospinning, Gelatin, Poly(ε-caprolactone), Mat
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